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Common side effects (10% or more of patients) Nausea Diarrhea Constipation Vomiting Reduced appetite (intended effect, but may feel uncomfortable initially) Stomach pain or discomfort Indigestion or acid reflux Fatigue Mild injection site reactions Serious side effects (rare but require immediate medical attention) Pancreatitis: severe, persistent abdominal pain that may radiate to the back, often with nausea or vomiting Gallbladder problems: upper right abdominal pain, fever, jaundice, or unusual stool color Severe allergic reactions: rash, swelling of the face or throat, difficulty breathing Kidney issues: often related to dehydration from prolonged vomiting or diarrhea Diabetic retinopathy complications in patients with pre-existing diabetic eye disease Severe hypoglycemia in patients also taking insulin or sulfonylureas Boxed warning: Tirzepatide caused thyroid C-cell tumors in animal studies

Tirzepatide works by mimicking two natural hormones in the body, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)

The peptide dosage calculation guide walks through these verification methods in more detail for all peptide types

Head-to-head comparison The choice between these formulations should match individual priorities