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Leptin levels decrease with fat mass reduction, signaling energy deficiency to the hypothalamus

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The placebo-subtracted fibrosis improvement was highly significant and in the range of prior agents considered in the MASLD field as antifibrotics, such as obeticholic acid (Intercept Pharmaceuticals), which was not approved by FDA for MASH on safety concerns) or resmetirom (Rezdiffra, Madrigal Pharmaceuticals), which is the first FDA-approved agent for the treatment of MASH

Previous study provided evidence for the presence of GLP-1 receptor in adipose tissue ( in vivo and in vitro , while increasing that of lipolytic markers and adiponectin ( In mammals, the white adipose tissue (WAT) is the major organ that stores extra energy from diets in the form of triglycerides (TG) or fat, which can be mobilized to meet energy demands ( 2 Methods 2.1 Mice A total of 36 male C57BL/6JC mice (7-week-old, 1620 g) purchased from Hebei INVIVO Laboratory Animal Technology Co., Ltd