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Monitor blood glucose levels more frequently, check ketones if advised by your healthcare team, and consider temporarily adjusting other diabetes medications (particularly insulin, metformin or SGLT2 inhibitors) after seeking clinical advice if you're unable to eat or drink normally

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The Nrf2-mediated induction of the pentose phosphate pathway at the transcription level would substantially increase the pathway activity in p53-mutated cancers

This quantitative understanding is now driving the development of pathway-specific inhibitors, such as PKC- selective antagonists, SGLT2 inhibitors, and glyoxalase-1, which have shown promise in preclinical models for breaking this cycle without globally suppressing physiologically important ROS signaling -Figure 3 (Oliveira et al., 2023