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Dihydroxyacetone (DHA), an ingredient used in many sunless tanning products, darkens the skin by reacting with amino acids on the skins surface

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Clin Rev Allergy Immunol 2003;24:201220

Overall, although the overall absolute risk increase is small (27 cases per 10,000 persons treated per year), clinical practitioners should nevertheless take into account the potential risk of gallbladder or biliary diseases associated with GLP-1RAs, especially when used at higher doses, for longer durations, and for weight loss, and in case the patient has a history of lithiasis [64]