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Phase 2 clinical trial data published in the New England Journal of Medicine (Jastreboff et al., 2023) demonstrated mean body weight reductions of up to approximately 24% over 48 weeks in adults with obesity a notable finding, though long-term durability data and head-to-head comparisons with other treatments are not yet available

They usually occur in the initial phase of starting the treatment or during dose escalation, but improve over time

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity (in Eng)

So, while its not a direct cure for anxiety or depression, getting enough B12 can definitely help support a better mood