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Intracellular Mechanisms Underlying Exendin-4-induced Suppression of GABA Currents GLP-1R has been reported to primarily act through G s [2, 43] and has also been shown to couple with the inhibitory G i/o proteins [40]

While SOD2 converts superoxide radicals to H 2 O 2 , the deficiency in downstream H 2 O 2 -detoxifying enzymes (CAT and peroxiredoxins) potentially leads to H 2 O 2 accumulation, exacerbating oxidative stress (Chen et al., 2008)

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