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Most commonly reported: Nausea (most common, particularly during dose escalation) Diarrhea Vomiting Constipation Abdominal discomfort These effects were generally mild to moderate in severity and tended to diminish as participants adjusted to the treatment, particularly when gradual dose escalation protocols were followed

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Physical activity is one of the most well-documented, mechanism-supported interventions for improving the same metabolic pathways that GLP-1 therapies target

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