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Q.ShenL.WangR.et al (2021)

GLP-1 is naturally produced in your intestines after eating, and it performs several important functions: [1] Slows gastric emptying, helping you feel fuller longer Signals the brain to reduce hunger and increase satiety Helps regulate blood sugar by stimulating insulin release Reduces glucagon secretion (which normally raises blood sugar) The weight loss and pharmaceutical industries have been revolutionized by prescription GLP-1 agonist medications, but these come with significant drawbacks - they're expensive, require injections, and worst of all, come with some brutal side effects, including muscle loss, GI distress, horribly long stomach emptying (gastroparesis), cancer risk, and even blindness

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274 , L134L142 (1998)