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Nathan DM (2022) Glycemic Outcomes in the glycemia reduction approaches in type 2 diabetes: a comparative effectiveness (GRADE) study

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The mean eGFR is based on the serum creatinine level and the Chronic Kidney Disease Epidemiology Collaboration 2009 equation

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While the people with PCOS seem to have some improved estrogen effects (ovulation), there is such a complex interplay between insulin, ILGF, SHBG, and sex steroid hormones, I dont think we can confidently say the pioglitazone drove the increased estrogen effects

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