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More importantly, the orally available RNK06395 ERK5-CHAMP showed promising anti-tumor effects, thus representing a potential ERK5-targeting therapy, since many available ERK5 specific small molecule inhibitors and ERK5 PROTAC are ineffective at reducing cancer cell proliferation [41, 42, 47]

Signs and symptoms of vitamin B12 deficiency can include fatigue, pale skin, headaches, shortness of breath, fast heartbeat, gastrointestinal issues, mouth inflammation, paresthesias (abnormal sensations), decreased cognitive ability, depression, muscle weakness, imbalance and incoordination, vision problems, and erectile dysfunction

Duenngai K, Sithithaworn P, Rudrappa UK, Iddya K, Laha T, Stensvold CR, Strandgaard H, Johansen MV