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A separate study from the same research group, using the same exercise protocol similarly showed significant reductions in A levels and increased microglia in the hippocampus in AD mice (Liu et al., 2020)

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Rather than simply suppressing symptoms, we can now target the underlying inflammatory pathways while simultaneously promoting repair and regeneration

Williams reported that while central blockade of the GLP-1 system with ICV administration of exendin 939 blocked the actions of central but not peripheral GLP-1, peripheral (intraperitoneal) exendin 939 blocked the appetite-suppressing actions of peripheral, but not central GLP-1, indicating that the two systems do not depend on each other for activity