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Although the action mechanism of SS-31 against kidney disease is not fully understood, the available studies suggest that it elicits its effects primarily by protecting mitochondrial structure, repairing damaged mitochondria, scavenging ROS, and increasing ATP supply, thereby reducing oxidative stress and improving apoptosis, inflammatory response, autophagy, and fibrosis [14, 27, 34] (Figure 1)

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Despite there being various techniques to encapsulate the drugs and increase encapsulation efficiency, the freeze-thaw cycling and reverse phase evaporation techniques are used extensively [135]