Following treatment withdrawal, semaglutide and placebo participants regained 11.6 (SD: 7.7) and 1.9 (SD: 4.8) percentage points of lost weight, respectively, by week 120, resulting in net losses of 5.6% (SD: 8.9%) and 0.1% (SD: 5.8%), respectively, from week 0 to week 120
In the phase 2 dose-finding trial, the highest dose of 4.5 mg weekly produced a dose-dependent weight reduction that, in the reported analysis, exceeded both placebo and the comparator liraglutide 3.0 mg Lau et al., 202101751-7/abstract)
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When acne scores taken after 1, 2, 3, 4, and 6 weeks of use were compared to baseline, there was no change after 1 week of product use. There was a 7.1%, 21.4%, 28.6% decrease (improvement) in the acne grade after 2, 3 and 4 weeks of product use, respectively. The improvements after 3 and 4 weeks of product use were statistically significant when compared to baseline