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In the anabolic methionine cycle, niacin, in the form of NAD, is a necessary co-factor for the enzymes dihydrofolate reductase in the folate/tetrahydrobiopterin cycle and S-adenosylhomocysteine hydrolase (1)

B12 Deficiency: Recognizing the Symptoms and Seeking Treatment A significant B12 deficiency is a serious health concern requiring prompt medical attention

Also, just to note, those with darker skin tones, need to really quite careful with things like salicylic peels as they can cause pigmentation

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