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Overall, HT pathogenesis results from a complex interplay between innate and adaptive immunity, where breakdowns in tolerance, skewed Th1/Th17/Treg balance, and persistent autoantibody production sustain chronic inflammation and irreversible thyroid destruction

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In everyday practice, this most often means somewhere between 0.05 mg and 0.2 mg per week, though there is no consensus clinical definition and no randomized controlled trial has tested a true microdose as a primary endpoint (Cedars-Sinai, Hackensack Meridian Health, STAT News)

Today's healthcare system poorly serves chronic conditions that require ongoing support outside of the exam room, like obesity, diabetes, hypertension, cholesterol, and musculoskeletal conditions