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Studies have shown that exposure to DEHP may affect estrogen metabolism and signal transduction 20,26 , and that abnormal estrogen levels or disordered estrogen signaling pathways increase the risk of BRCA 27

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This potentially suggests a relationship between deiodinases and brain development, though likely through thyroid hormone mechanisms ( Selenoprotein P (SELENOP, SepP) SELENOP is unique in that is has 10 Sec residues, as opposed to 1 sec residue in all other selenoproteins ( SELENOP is expressed itself in many tissues, including the brain ( Selenoprotein R (SELENOR, SELR, and MsrB1) SELENOR is a methionine sulfoxide reductase

The origin of chondrocytes in the nucleus pulposus and histologic findings associated with the transition of a notochordal nucleus pulposus to a fibrocartilaginous nucleus pulposus in intact rabbit intervertebral discs