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In conclusion, BARI-STEP, a randomized, placebo-controlled trial investigating the use of once-weekly semaglutide 2.4 mg in a post-bariatric patient population with a suboptimal clinical response, demonstrates that semaglutide 2.4 mg in patients with a suboptimal clinical response results in substantial, clinically relevant body weight reduction, and improvements in metabolic health and quality of life

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Stacking Protocols Stacking with other GLP-1 agonists (tirzepatide, liraglutide) is described as redundant overlapping mechanisms increase side effects without proportional benefits