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The AZIN1 gene is located on chromosome 8q22.3 and is composed of 13 exons that generate 10 alternatively spliced mRNAs that collectively encode four distinct protein isoforms

Obesity is prevalent in approximately 40% of PCOS patients, with 70% of obese individuals exhibiting at least one abnormal lipid parameter ( Figure 1 2 Factors affecting the occurrence and development of PCOS The pathogenesis of PCOS is multifactorial, involving genetic predisposition, metabolic dysregulation, endocrine abnormalities, immune imbalance, and environmental influences, all of which interact to contribute to the disease phenotype

Pain modulation and interaction with endogenous opioid systems represent another productive area of DSIP investigation

Human and Animal Rights and Informed Consent This review was based on previously published studies and publicly available data and did not involve any new studies of human participants or animals performed by the authors