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Particularly, BTK seems to play a significant role in microglial proliferation when these cells are exposed to anti-MOG antibodies (181)

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Studies have demonstrated that although antibiotics do not play a significant role in treating UC in all trails, broad-spectrum oral antibiotic cocktails have reported a possible role in acute severe colitis and chronic persistent UC [153156] .However, a systematic review of 12 randomized controlled trials (RCTs, include 847 participants) reported that no difference between antibiotics and placebo in the proportion of patients in clinical remission at the end of the intervention period [157]