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The review noted that while whole foods should be the first line of defense, reduced caloric intake from appetite suppression creates real nutritional gaps that dietary supplements may help address

Beyond the two primary proteins of focus in ADRD progression, glymphatic clearance also helps support removal of inflammatory markers to maintain the parenchymal environment and reduce neurotoxic load on neurons (Mogensen et al., 2021)

Whole foods approach: Investing 12 monthly in extra vegetables, lean proteins, and whole grains provides guaranteed nutritional benefits and supports sustainable weight loss

PMID 28892235