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Carnitine O -acetyltransferase Carnitine O -acetyltransferase (CrAT), located primarily in the mitochondrial matrix, catalyzes the addition or the removal of carnitine from medium- and short-chain acyl-CoA 60,61 , facilitating the efflux of mitochondrial acetyl-CoA to the cytosol and buffering the intracellular pools of acetyl-CoA and carnitine

Like most dietary supplements, it works best when paired with proper hydration, nutrition, and regular physical activity

GLP-1 agonists should not be used in combination with DPP-4 inhibitors

The inhibition of GLS got the attention due to the dysregulation of GLS in a variety of cancers