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Patients are randomly assigned to groups (randomised), the person assessing results doesn't know who got what (single-blind), and the comparison group receives a dummy treatment (placebo-controlled)

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It is a biomarker of lipoperoxidation resulting from arachidonic and larger PUFA degradation and is generated by enzymatic and non-enzymatic processes (Ayala et al., 2014)

For those interested in the underlying clinical mechanisms, learning more about the ultimate skin brightening secret of glutathione can be highly beneficial