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A waterfall plot of %WL between groups is illustrated in Supplementary Fig

Insulin resistance is the inadequate response of target tissues to the physiological effects of circulating insulin, such as decreased glucose uptake in skeletal muscles under insulin stimulation, inhibition of hepatic gluconeogenesis by insulin, and relief of the inhibitory effect of insulin on lipid breakdown in adipose tissue ( The main cause of the prevalence of obesity is the long-term imbalance between calorie intake and expenditure