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The STEP 1 trial demonstrated a mean body weight reduction of 14.9% at this dose after 68 weeks, with 86.4% of participants achieving at least 5% weight loss and 69 to 79% achieving 10% or more

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Disruption of the AMPKOXPHOS axis has been shown to sensitize CSCs to chemotherapy, underscoring its potential as a therapeutic target [61]

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