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663 This is partly due to mutations in the von HippelLindau protein in some aggressive tumors, which impairs the degradation of HIF-1

Currently, once-weekly subcutaneous semaglutide 2.4 mg is approved for chronic weight management in adults with obesity, or overweight and with at least one weight-related comorbidity 17 , for reducing CV risk in adults with established cardiovascular disease (CVD) with obesity or overweight 18 , and in adolescents aged 12 years and older 19 , in conjunction with a reduced-calorie diet and increased physical activity plan

The quality of each included RCT was assessed by the Cochrane Risk-of-Bias Tool 1.0