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Key results at 80 weeks: Participants on the 4 mg dose lost an average of 47.2 lbs (19.0%) Participants on the 12 mg dose lost an average of 70.3 lbs (28.3%) 45.3% of participants on the 12 mg dose achieved at least 30% weight loss a level historically associated with bariatric surgery outcomes The 4 mg dose showed a lower rate of discontinuation due to adverse events than even placebo In a study extension to 104 weeks, participants with a starting BMI of 35 or higher who received 12 mg lost up to an average of 85.0 lbs (30.3%)

The broader question of whether stacking an amylin analogue onto a GLP-1 drug earns its place is exactly what the REDEFINE program was built to answer, and it is discussed further in whether research validates cagrilintides role in appetite regulation

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Zonulin as a potential putative biomarker of risk for shared type 1 diabetes and celiac disease autoimmunity