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Further exemplifying how observations in 22q11DS can provide valuable insights for our understanding of disease mechanisms in idiopathic cases, an additional study reported a significant association between the polygenic score for schizophrenia and cognitive decline in 22q11DS, thus indicating that the modification of these phenotypes in 22q11DS occurs at least partly under the influence of the same common genetic risk variants [92]

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Interestingly, the age-dependent decrease in methionine synthase, the target of mB12 in the methionine pathway, may be accelerated in the ASD brain (Muratore et al., 2013)

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