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Due to the promotive effect of GLP-1R agonism on -cells proliferation and survival, concerns of tumorigenesis, especially pancreatic cancers, have been raised about incretin-based therapies ( 4.5 Asthma Asthma is a very common chronic lung disease characterized by chronic persistent airway inflammation and airway remodeling, resulting in incompletely reversible airway obstruction, especially in advanced stages ( 5 Discussion The safety and efficacy of GLP-1RAs in the treatment of type 2 diabetes have been well demonstrated

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accordingly, they are closely related to cancer, including PTC

Kidney overload: High levels of vitamin B12 require the kidneys to work harder to eliminate it, which could lead to kidney stress and, in severe cases, kidney damage