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This parental line, which intrinsically expresses minimal CFTR protein, serves as a reliable model and is frequently used as a null-background for the stable overexpression of wild-type, F508del, or other CFTR variants, enabling the study of their function and response to modulators (Ousingsawat et al., 2011

14 In contrast, studies report that administering GABA-A receptor antagonists to rodents in the striatum and intra-cortex induces twitching symptoms, which can be alleviated by the administration of GABA-A receptor agonists

doi:10.2337/db13-0887