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oestradiol (E2) bind ER or ER in mammary epithelial cells, followed by receptor dimerisation, nuclear translocation and direct transcriptional regulation of EREs in promoter regions on target genes that regulate cell proliferation cyclin D1, c-Myc -, survival Bcl-2 or survivin -, angiogenesis VEGF -, EMT Snail, Twist -, metastasis MMPs (185), as non-genomic oestrogen signalling via membrane-localized ER and G proteincoupled oestrogen receptor (GPER) leads to rapid stimulation of PI3K/Akt, MAPK/ERK and Src pathways interacting further impetus to mitogenic and anti-apoptotic effects

This directly controls how cells migrate to repair sites, how they restructure damaged tissue scaffolding, and how quickly the cellular response to injury organizes itself

Robuffo, G

It contains two established research peptides CJC1295 and Ipamorelin enabling researchers to study combined peptide activity, crosspathway interactions, and receptorsignalling behaviour within multicompound experimental systems