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In people with reduced ALDH2 levels (and thus more acetaldehyde), alcohol is more likely to induce asthma.[ref] One study explains: Impaired ALDH2 activity leads to high peak levels of acetaldehyde and to histamine release. Studies show that inhaling acetaldehyde induces histamine-mediated airway constriction, such as is seen in asthma.[ref] Hangovers and histamine A recent animal study sheds light on the age-old question of what causes hangover symptoms

Your personal comfort level and daily routine are important considerations

At the upper arm and thigh, err toward the shorter end because subcutaneous fat at these sites is generally thinner

Yes, when supervised by qualified physicians