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Saxenda also slows stomach emptying

Journal of Visualized Experiments, 2011

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Concretely, p300-dependent lactylation of HMGB1 facilitates its translocation into lysosomes in the cytoplasm of macrophages and release via exosome secretion, disrupting endothelium barrier function by decreasing VE-cadherin and claudin 5 expression and increasing ICAM1 expression in human umbilical cord endothelial cells (HUVECs)