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Br Med Bull 1997, 53:307-321

Patients experiencing persistent or severe gastrointestinal symptoms should consult their healthcare provider, as dose adjustment or temporary dose reduction may be appropriate

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Clinical testing showed improved hyperpigmentation after 4 weeks of use. Skin tone evenness improved by 18.90%, and the formula completed dermatologist testing and skin irritation testing with a 0.00% irritation rate. It's a gentle formulation that even sensitive skin can use with confidence