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Similarly, the hearts of db/db mice were shown to have decreased cardiac function because of lower NRF2 levels and Gclc / Gclm expression in the aorta and arterioles, leading to decreased GSH levels, which could be reversed by treatment with SF (128)

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Medical conditions that may explain prolonged fatigue exclude a patient from the diagnosis of CFS, as do a number of psychiatric illnesses such as melancholic depression, bipolar disorder, psychotic disorders, eating disorders, or substance use disorder within two years of the onset of fatigue (Afari and Buchwald 2003)