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In hemochromatosis (a model of systemic iron overload), erythrocytes display increased PS exposure, elevated calpain activity (a cysteine protease mediating cytoskeletal degradation during eryptosis), and reduced deformabilitychanges that enhance splenic macrophage clearance (du Plooy et al., 2018

Furthermore, neutrophils are able to cause lipid peroxidation in glioblastoma cells by incorporating myeloperoxidase (61)

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