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During melanoma progression, E-cadherins are progressively reduced to allow for the dissociation between melanocytes and keratinocytes followed by concomitant upregulation of N-cadherins to support melanoma cell survival, and migration through tissues, a process regulated by the PI3K/AKT pathway (5456)

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Sponsors can identify emerging risks earlier, optimize dosing strategies, and refine protocols mid-study, capabilities that are especially valuable in fast-moving GLP-1 programs