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Patients who take part in a clinical trial may receive the standard treatment or be among the first to receive a new treatment

It results from an imbalance in the generation and removal of free radicals by cells ( Class III histone deacetylases, known as sirtuins, use one NAD+ molecule for each cycle of deacetylation ( New oral antidiabetic medications, known as sodiumglucose co-transporter 2 inhibitors (SGLT2 I) can effectively treat type 2 diabetes mellitus (T2DM) by increasing renal glucose excretion through an insulin-independent mechanism ( 2 Materials and methods 2.1 Animals Twenty-four mature male Wistar rats, weighing 180220 g and between 6 and 8 weeks old, were donated by the Animal House Colony at the National Research Centre (NRC, Egypt)