It is not naturally produced in the body and is primarily found in supplements
Ongoing studies continue to expand our understanding of its role in antioxidant defense, mitochondrial physiology, detoxification pathways, immune regulation, and cellular resilience under conditions of physiological stress
Randomized clinical studies in rodents and older adults indicate that glutathione acts in concert with the independent actions to two key precursors, glycine and and cysteine, to improve an array of biomarkers associated with the hallmarks of aging
Moreover, administration of N-acetyl cysteine (NAC) or ascorbate, antioxidants that increase tissue glutathione levels, abolished ovariectomy-induced bone loss, while L-buthionine-(S,R)-sulphoximine (BSO), a specific inhibitor of glutathione synthesis, caused substantial bone loss