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However, human clinical safety data remain extremely limited

A study by De Flora et al

The enzyme activity is expressed as nmol/mg protein/min

Liver metabolism during glucouronidation or sulfation, CYP activity and maintenance of hepatic GSH supply depends on patient factors such as age, nutritional status, pre-existing liver disease, concurrent use of alcohol and other liver-metabolized medications, genetic predispositions, and most importantly, the acuity or chronicity of APAP overuse.3,15,17,2030 Table 1