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Interestingly, N-acetylcysteine (NAC) which readily enters cells to convert to cysteine for GSH generation, is an important antioxidant 13

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These new findings encourage a novel working hypothesis for further research, that a chemical-modification mechanism enables transformation of HGF through interaction or reaction with LASSS under physiological conditions, resulting in the retention of HGFs biological activity after exposure to peroxynitrite, at least until an enhanced form of HGF undergoes metabolic turnover in vivo