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Thyroid diseases are the most common endocrine system disorders, affecting an estimated 5% of the US population, with Graves disease and Hashimotos thyroiditis accounting for a vast majority of cases. , Despite their prevalence, the underlying causes of thyroid autoimmunity remain complex and multifactorial, evolving over time and involving a perfect storm of risk factors: a genetic predisposition, environmental triggers, and an imbalanced immune system

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Since enhancement is not observed in normal kidneys, it is proposed that renal Epo gene expression is not fully induced by anemia due to anemia-provoked oxidative stress

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