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( Metabolites of the kynurenine pathway, 3-HK, and QUIN, are known pro-oxidative metabolites, forming superoxide, hydroxyl radical, and hydrogen peroxide ( 2 O 2 ( We presented the association of oxidative stress with depressive disorder in children and adolescents in a recent paper ( Figure 1 ) is increased and that H 2 O 2 formed during the catalytical reaction can trigger lipoperoxidation and oxidative damage to proteins ( Table 3 )