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Applications of Quantitative Structure-Activity Relationships (QSAR) based Virtual Screening in Drug Design: A Review

In recent years, the concept of the gut-brain axis has highlighted that gut microbes not only participate in nutrient metabolism and maintenance of mucosal immune homeostasis but may also engage in bidirectional communication with the CNS via neuroendocrine, immune, and metabolite-mediated pathways ( The liver and intestine are anatomically and functionally interconnected through the portal venous circulation, forming the gut-liver axis ( In this narrative review, we integrate recent advances in gut microbiology, hepatology, and anesthesiology to explore potential mechanisms linking the gut microbiota to POD