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Tie-2 is the tyrosine kinase receptor for Ang-1 and Ang-2, molecules that regulate angiogenesis and endothelial cell survival, proliferation and migration ( 2 -integrin on monocytes, which interacted with ICAM-1 expressed by endothelial cells and thereby facilitated the migration of monocytes, leading to accumulation of monocyte-derived macrophages in the TME (7880)

Sequence: Y-Aib-E-G-T-F-T-S-D-Y-S-I-L-L-D-K-Aib-A-Q-Aib-A-F-I-E-Y-L-L-E-G-G-P-S-S-G-A-P-P-P-S-NH2

Consequently, EESCs secrete angiogenic factors in a paracrine fashion, thereby fueling neovascularization (29) and further advancing endometriosis pathogenesis

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