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Mechanistic Studies in Gnotobiotic Models: Animal models where the microbiome is controlled (germ-free or colonized with defined communities) are invaluable for proving mechanistic links

Doxorubicine-congestive heart failure-increased big endothelin-1 plasma concentration: Reversal by amlodipine, losartan, and gastric pentadecapeptide BPC157 in rat and mouse J Pharmacol Sci, 95 (1) (2004), pp

In humans, as also observed in mouse models, transplantation of the gut microbiome of healthy people into patients with metabolic syndrome increases the insulin sensitivity of the recipients [62]

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