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As a result, contemporary guidelines, including those from the American Academy of Orthopaedic Surgeons (AAOS) and OARSI, strongly advise against routine arthroscopic surgery for degenerative OA in the absence of clear mechanical indications such as unstable meniscal tears or loose bodies (Moseley et al., 2002

However, it should not be applied on open wounds or broken skin

The agency cited safety risks including potential carcinogenicity, immunogenicity, and concerns about impurities and noted that most of these substances had never undergone rigorous human clinical trials

10.1080/03235400903266297 26 DingS.LuQ.ZhangY.YangZ.WenX.ZhangL.et al