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Patients on metformin at a dose of at least 1,500 mg per day were randomized following a 2-week placebo lead-in period to glipizide or dapagliflozin (5 mg or 2.5 mg, respectively) and were up-titrated over 18 weeks to optimal glycemic effect (FPG 300 mg/g)

Anti-inflammatory action: GIP signaling suppresses inflammatory factor release (e.g., IL-6, TNF-), while GCGR activation promotes chondrocyte proliferation

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Based on Eli Lilly's pricing for Mounjaro/Zepbound (~$1,060/month) and the competitive GLP-1 market, retatrutide's commercial list price is estimated at $1,000$1,500 per month