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Seek urgent care or emergency help for symptoms such as severe abdominal pain, persistent vomiting or diarrhea, signs of dehydration, trouble breathing or swallowing, swelling of the face, lips, tongue, or throat, fainting, yellowing skin or eyes, or any symptom your clinician has told you to treat as urgent
New washout period for rectal glucocorticoids WADA has now included washout times for glucocorticoids administered by the rectal route
In a mouse model of diabetes, topiramate effectively protected the brain from diabetes-induced damage by reducing 4-HNE levels and increasing glutathione (GSH) levels ( However, in a study on the potential toxic effects of topiramate on the liver and kidney of male mice, topiramate significantly decreased the activities of the antioxidant enzymes SOD and CAT, while increasing MDA and NO levels ( In vitro study found that topiramate increased MDA, NO and ROS production in astrocytes, showing a dose-dependent negative effect ( These findings suggest that topiramate may exert dual effects on oxidative stress, offering neuroprotection in certain contexts while exacerbating oxidative stress under different conditions and dosages
