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Participants with MCI required a CDR global score of 0.5 along with a CDR domain score of 0.5 in at least one of the three activities of daily living categories (personal care, home and hobbies, community affairs) to promote the enrollment of participants with late MCI due to AD who may be more likely to progress to dementia during the trial (compared with people with CDR global score of 0.5 without impairment in activities of daily living categories) [53]

Altered skin sensation (including dysesthesia, hyperesthesia, allodynia, and paresthesia) and alopecia were found to be significantly associated with a 50mg weekly dose of oral semaglutide, though the mechanisms and risk factors for these events remain to be characterized (136)

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