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Based on her presentation with a vasculitic suspicious rash and fatigue, an autoimmune panel was conducted, yielding the following results: positive ANA direct, elevated double-stranded DNA at 123 IU/ml, positive anti-histone antibody, low C4 (5 mg/dl), and normal C3 (92 mg/dl) levels

doi:10.1210/jc.2005-0375 Vanderpump MP, Tunbridge WM, French JM, et al

Energy drinks may give a quick boost but can cause crashes

The current strategies addressing these issues range from structural modifications (e.g., peptide cyclization, D-amino acid substitution, cationization, pegylation, addition of fatty acid chains), to formulation improvements using permeation enhancers, enteric coatings, enzyme inhibitors, polymers for controlled drug release, micro-/nanocarriers, targeted drug delivery, and physical devices [156]